Risk factors: HPV infection (16, 18, 33, 35) Smoking Alcohol use (synergistic with smoking) Betelnut chewing Genetic factors such as Fanconi Anemia (avoid alkylating agents and radiation due to increased toxicity in these patients) Sites of tumor: Oral Cavity: mucosal lip, Buccal mucosa, anterior tongue, hard palate Oropharyngeal Cancer: upper throat, tonsil, base of tongue, soft palate, pharyngeal wall Hypopharyngeal Cancer (lower throat) Laryngeal Cancer Treatment: Principl

This post is a summary of work-up, staging and treatment of perianal and anal squamous cell carcinoma.