Lymphoma (Snap Review)

Hodgkin lymphoma (HL): B-cell lymphoma

Non-Hodgkin lymphomas (NHL):

• B-cell lymphomas (85–90%):

  • DLBCL:

    • The most common, aggressive

  • Follicular lymphoma (FL):

    • Indolent, arising from germinal center B cells

  • Marginal zone lymphoma (MZL):

    • Extranodal, Nodal, Splenic

  • Mantel cell lymphoma (MCL):

    • More aggressive, Derived from mantle zone B cells

  • Burkit lymphoma (BL):

    • Highly aggressive, germinal center origin

  • Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)

  • Lymphoplasmacytic lymphoma (LPL)

  • Hairy cell leukemia

  • High-grade B-cell lymphomas (LGBL)

• T-cell lymphomas (10-15%):

  • Peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS):

    • Most common

  • Angioimmunoblastic T-cell lymphoma (AITL):

    • Often presents with systemic symptoms and immune dysregulation

  • Anaplastic large cell lymphoma (ALCL):

    • Can be ALK-positive or ALK-negative

  • Enteropathy-associated T-cell lymphoma (EATL):

    • Associated with celiac disease

  • Hepatosplenic T-cell lymphoma

  • Adult T-cell leukemia/lymphoma

  • T-cell large granular lymphocytic leukemia (T-LGLL):

    • Less common, often with extranodal involvement

Immunophenotype characteristics:

• Black cells: Positive

For example: CLL has CD5 +

• White cells: Negative

For example: FL has CD5 –

• Gray cells: Weak/dim

For example: CLL has weak CD20

• Black cells with white circles: Positive, occasionally negative

For example: FL often has positive CD10, but can be negative as well.

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